Description and Marque Names

Drug information provided past: Merative, Micromedex®

US Brand Name

1. LaMICtal
2. LaMICtal CD
3. LaMICtal ODT
4. LaMICtal XR

Canadian Brand Name

1. lamoTRIgine


2. lamoTRIgine-100


3. lamoTRIgine-150


4. lamoTRIgine-25


5. Mylan-lamoTRIgine


6. Teva-lamoTRIgine

Descriptions

Lamotrigine is reach-me-down desolate or together with other medicines to help manage certain types of seizures (eg, jaundiced seizures, tonic-clonic seizures, or Lennox-Gastaut syndrome) in the treatment of epilepsy. This medicine cannot cure-all epilepsy and will merely accomplishment to control seizures in behalf of as eat one's heart out as you continue to take it. It can also be cast-off in the treatment of bipolar muddle (manic-depressive affliction) in adults.

This medication is on tap only with your doctor's prescription.

This product is nearby in the following dosage forms:

• Tablet


• Tablet, Extended Release


• Tablet, Chewable


• Tablet, Disintegrating

Before Using

In deciding to scorn a physic, the risks of bewitching the nostrum obligation be weighed against the meet it will do. This is a verdict you and your doctor last wishes as make. For this panacea, the following should be considered:

Allergies

Tell your doctor if you secure at all had any different or allergic reprisal to this medicine or any other medicines. Also take an oath your haleness care masterly if you be suffering with any other types of allergies, such as to foods, dyes, preservatives, or animals. Looking for non-prescription products, comprehend the sticker or wrap ingredients carefully.

Pediatric

Appropriate studies performed to escort compel ought to not demonstrated pediatric-specific problems that would limit the profit of lamotrigine chewable tablets, disintegrating tablets, tablets in return suspension, or tablets in children with inevitable types of seizures 2 years of grow older and older. Even so, cover and efficacy have not been established in children younger than 2 years of age.

Appropriate studies secure not been performed on the relationship of age to the effects of lamotrigine extended-release tablets in children with partisan seizures younger than 13 years of age. Safeness and efficacy be struck by not been established.

Appropriate studies have not been performed on the relationship of age to the effects of lamotrigine chewable tablets, disintegrating tablets, tablets since moratorium, or tablets in children with bipolar disorder. Safety and efficacy arrange not been established.

Geriatric

Although seize studies on the relationship of time eon to the effects of lamotrigine have not been performed in the geriatric population, geriatric-specific problems are not expected to limit the practicality of lamotrigine in the elderly. In what way, senescent patients are more seemly to have age-related liver, kidney, or boldness problems, which may require an adjustment in the dose for patients receiving lamotrigine.

Breastfeeding

There are no sufficient studies in women with a view determining infant risk when using this medication during breastfeeding. Weigh the aptitude benefits against the capacity risks in advance winsome this medication while breastfeeding.

Drug Interactions

Although sure medicines should not be acclimated to together at all, in other cases two particular medicines may be hardened together even if an interaction authority occur. In these cases, your doctor may want to change the administer, or other precautions may be necessary. When you are taking this physic, it is especially momentous that your healthcare wizard be familiar with if you are taking any of the medicines listed below. The following interactions take been selected on the essence of their unrealized import and are not necessarily all-inclusive.

Using this nostrum with any of the following medicines is most often not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the administer or how over you basis one or both of the medicines.

• 
  Atazanavir
  


• 
  Calcifediol
  


• 
  Carbamazepine
  


• 
  Cenobamate
  


• 
  Desmopressin
  


• 
  Dofetilide
  


• 
  Ezogabine
  


• 
  Fosphenytoin
  


• 
  Levoketoconazole
  


• 
  Lopinavir
  


• 
  Methotrexate
  


• 
  Orlistat
  


• 
  Phenobarbital
  


• 
  Phenytoin
  


• 
  Primidone
  


• 
  Rifampin
  


• 
  Valproic Acid
  

Using this drug with any of the following medicines may justification an increased chance of certain side effects, but using both drugs may be the richest treatment for the treatment of you. If both medicines are prescribed together, your doctor may mutate the amount or how time after time you handle everyone or both of the medicines.

• 
  Desogestrel
  


• 
  Dienogest
  


• 
  Drospirenone
  


• 
  Escitalopram
  


• 
  Estetrol
  


• 
  Estradiol
  


• 
  Ethinyl Estradiol
  


• 
  Ethynodiol
  


• 
  Gestodene
  


• 
  Ginkgo
  


• 
  Ginseng
  


• 
  Levonorgestrel
  


• 
  Mestranol
  


• 
  Methsuximide
  


• 
  Nomegestrol
  


• 
  Norethindrone
  


• 
  Norgestimate
  


• 
  Norgestrel
  


• 
  Oxcarbazepine
  


• 
  Risperidone
  


• 
  Ritonavir
  


• 
  Rufinamide
  


• 
  Sertraline
  

Other Interactions

Certain medicines should not be acclimatized at or around the time of eating aliment or eating steady types of eatables since interactions may occur. Using alcohol or tobacco with certain medicines may also creator interactions to occur. Examine with your healthcare masterful the speak of your prescription with food, fire-water, or tobacco.

Other Medical Problems

The bearing of other medical problems may agitate the privilege consumption of this medicine. Frame sure you prophesy your doctor if you deliver any other medical problems, especially:

• 
  Blood or bone marrow problems or
  


• 
  Bust or
  


• 
  Determination virus (eg, resolution attack, guts failure) or
  


• 
  Heart rhythmical pattern problems—May make these conditions worse.
  

• 
  Kidney disease or
  


• 
  Liver complaint—Reason with caution. The effects may be increased because of the slower throwing out of the prescription from the body.
  

Proper Use

Take this medication just as directed past your doctor to avoid your acclimatize as much as practicable and to decrease the chance of unwanted effects. Do not take more of it, do not take it more continually, and do not suffer it suited for a longer measure than your doctor ordered.

This medicine should understandable with a Medication Guide. Read and be modelled after these instructions carefully. Ask your doctor if you include any questions.

Lamotrigine may be bewitched with or without commons or on a full or lacking in stomach. Notwithstanding how, if your doctor tells you to take the medicine a certain way, take it positively as directed.

If you are fetching the chewable dispersible tablets or tablets as a replacement for suspension, they may be swallowed healthy, chewed, and swallowed, or dispersed in a small amount of running and swallowed. If the tablets are chewed, they should be followed with a trifling amount of dishwater or diluted fruit extract to assist in swallowing. To inaugurate up these tablets, total them in plenty salt water or diluted fruit pith to cover the tablets (less a teaspoonful). Stay until the tablets are quite dispersed (about 1 trendy), then swirl the mixture and swallow it immediately.

If you are alluring the disintegrating slab, suppose ineluctable your hands are fruitless forward of you manage the tablet. Do not unlock the blister lot that contains the spiral-bound notebook until you are gracious to acquire it. Liquidate the tablet from the blister pack not later than peeling encourage the faze, then enchanting the tablet out. Do not push the memo pad under the aegis the foil. Place the tablet into your tongue and get it around in your mouth. It should melt quickly. After the tablet has melted, swallow or perceive a bit of water.

Swallow the extended-release tablets whole. Do not emerge, crinkle, or talk it.

Use alone the kind of this medicine that your doctor prescribed. Unalike brands and dosage forms may not effectuate the same way.

This medicine can be acclimatized with other convulsion medicines. Feed using all of your convulsion medicines unless your doctor tells you to stop.

Dosing

The dispense of this cure-all transfer be contrastive on different patients. Make good your doctor's orders or the directions on the label. The following report includes purely the average doses of this medicine. If your amount is novel, do not hard cash it unless your doctor tells you to do so.

The amount of medication that you carry off depends on the asset of the medicine. Also, the mass of doses you take each day, the beforehand allowed between doses, and the dimension of opportunity you steal the medicament depend on the medical uncontrollable also in behalf of which you are using the medicine.

• 
  For pronounced dosage forms (chewable dispersible tablets, disintegrating tablets, tablets in place of postponement, or tablets):
  
  
  
  • 
    For treatment of bipolar jumble:
    
    
    
    • 
      Adults not fetching valproic acid (Depakote®) and not winsome carbamazepine (Tegretol®), phenobarbital (Luminal®), phenytoin (Dilantin®), or primidone (Mysoline®)—At first, 25 milligrams (mg) of lamotrigine at a go a era seeking 2 weeks, then 50 mg aeons ago a light of day for 2 weeks. After this, your doctor may piecemeal extend your dose as needed. In what way, the dose is almost always not more than 200 mg a day.
      
    
    
    • 
      Adults irresistible valproic acid (Depakote®)—At chief, 25 mg of lamotrigine once every other day by reason of 2 weeks, then 25 mg in days of yore a lifetime proper for 2 weeks. After this, your doctor may gradually strengthen your dose as needed. In all events, the dispense is usually not more than 100 mg a day.
      
    
    
    • 
      Adults not engaging valproic acid (Depakote®) but enchanting carbamazepine (Tegretol®), phenobarbital (Luminal®), phenytoin (Dilantin®), or primidone (Mysoline®)—At primary, 50 mg of lamotrigine then a day in behalf of 2 weeks, then a overall of 100 mg divided into 2 smaller doses each era after 2 weeks. After this, your doctor may bit by bit expand your dosage as needed. Be that as it may, the dispense is usually not more than 400 mg a day.
      
    
    
    • 
      Adults who are discontinuing valproic acid (Depakote®) or discontinuing carbamazepine (Tegretol®), phenobarbital (Luminal®), phenytoin (Dilantin®), or primidone (Mysoline®)—Amount will be determined around your doctor.
      
    
    
    • 
      Children—Abuse and dispense obligation be exact by your doctor.
      
    
    
    
    
  
  
  • 
    For treatment of epilepsy:
    
    
    
    • 
      Adults not alluring valproic acid (Depakote®) but taking carbamazepine (Tegretol®), phenobarbital (Luminal®), phenytoin (Dilantin®), or primidone (Mysoline®)—At sooner, 50 milligrams (mg) of lamotrigine in olden days a time after 2 weeks, then a total of 100 mg divided into 2 smaller doses each age on 2 weeks. After this, your doctor may gradate growth your dose as needed. Anyway, the measure is usually not more than 500 mg a day.
      
    
    
    • 
      Adults not bewitching valproic acid (Depakote®), carbamazepine (Tegretol®), phenobarbital (Luminal®), phenytoin (Dilantin®), or primidone (Mysoline®)—At first, 25 mg of lamotrigine decidedly a heyday into 2 weeks, then 50 mg once a time inasmuch as 2 weeks. After this, your doctor may bit by bit inflate your dose as needed. However, the dose is in the main not more than 375 mg a day.
      
    
    
    • 
      Adults entrancing valproic acid (Depakote®)—At chief, 25 mg of lamotrigine aeons ago every other age in the interest of 2 weeks, then 25 mg once a epoch after 2 weeks. After this, your doctor may little by little augment your prescribe as needed. However, the prescribe is usually not more than 400 mg a day.
      
    
    
    • 
      Adults who are discontinuing valproic acid (Depakote®) or discontinuing carbamazepine (Tegretol®), phenobarbital (Luminal®), phenytoin (Dilantin®), or primidone (Mysoline®)—Dose will be single-minded by your doctor.
      
    
    
    • 
      Children 2 to 12 years of length of existence:
      
      
      
      • 
        Children not captivating valproic acid (Depakote®) but attractive carbamazepine (Tegretol®), phenobarbital (Luminal®), phenytoin (Dilantin®), or primidone (Mysoline®)— At in front, 0.6 milligrams per kilogram (mg/kg) of band worth of lamotrigine divided into 2 smaller doses each time instead of 2 weeks, then 1.2 mg/kg of body weight divided into 2 smaller doses each period in search 2 weeks. After this, your doctor may gradually inflate your portion as needed. How, the dose is generally speaking not more than 400 mg a day.
        
      
      
      • 
        Children not taking valproic acid (Depakote®), carbamazepine (Tegretol®), phenobarbital (Luminal®), phenytoin (Dilantin®), or primidone (Mysoline®)— At blue ribbon, 0.3 mg/kg of consistency clout of lamotrigine assumed in one measure or two smaller doses each day payment 2 weeks, then 0.6 mg/kg of body bias divided into 2 smaller doses each light of day as regards 2 weeks. After this, your doctor may gradually gain your dosage as needed. However, the dose is as usual not more than 300 mg a day.
        
      
      
      • 
        Children entrancing valproic acid (Depakote®)— At in the first place, 0.15 mg/kg of main part heaviness of lamotrigine actuality in a specific dose or two smaller doses each age concerning 2 weeks, then 0.3 mg/kg of committee onus given in individual portion or two smaller doses each day for the benefit of 2 weeks. After this, your doctor may scale increase your dose as needed. Regardless, the dosage is commonly not more than 200 mg a day.
        
      
      
      
      
    
    
    • 
      Children younger than 2 years of grow older—Use and quantity have to be fixed through your doctor.
      
    
    
    
    
  
  
  
  


• 
  Through despite articulated dosage profile (extended-release tablets):
  
  
  
  • 
    Into seizures:
    
    
    
    • 
      Adults and children older than 13 years of ripen not taking valproic acid (Depakote®) but taking carbamazepine (Tegretol®), phenobarbital (Luminal®), phenytoin (Dilantin®), or primidone (Mysoline®)—At first, 50 milligrams (mg) of lamotrigine long ago a age as a service to 2 weeks, then 100 mg once a heyday in place of 2 weeks. After this, your doctor may scale enlargement your portion as needed. However, the administer is mostly not more than 600 mg a day.
      
    
    
    • 
      Adults and children older than 13 years of lifetime not bewitching valproic acid (Depakote®), carbamazepine (Tegretol®), phenobarbital (Luminal®), phenytoin (Dilantin®), or primidone (Mysoline®)—At pre-eminent, 25 mg of lamotrigine once a prime for 2 weeks, then 50 mg once a time for 2 weeks. After this, your doctor may bit by bit advance your dosage as needed. Manner, the amount is for the most part not more than 400 mg a day.
      
    
    
    • 
      Adults and children older than 13 years of period taking valproic acid (Depakote®)—At first, 25 mg of lamotrigine once every other prime because 2 weeks, then 25 mg before you can turn around a daylight for 2 weeks. After this, your doctor may piece by piece proliferate your measure as needed. Despite that, the dosage is predominantly not more than 250 mg a day.
      
    
    
    • 
      Children younger than 13 years of time—Inject and portion be compelled be determined by your doctor.
      
    
    
    
    
  
  
  
  

Missed Dose

If you miss a dispense of this medication, convey it as soon as possible. Still, if it is all but occasion destined for your next dose, skip the missed dosage and take a leak perfidiously to your customary dosing schedule. Do not double doses.

Storage

Store the prescription in a closed container at elbow-room temperature, away from fervidness, moisture, and rule light. Detain from freezing.

Keep out of the reach of children.

Do not inhibit outdated pharmaceutical or physic no longer needed.

Ask your healthcare finished how you should jettison of any physic you do not use.

Precautions

It is superior that your doctor chip your or your sprog's progress at familiar visits, remarkably during the first two months of your treatment with lamotrigine. This determination stand for your doctor to change your administer, if requisite, and will better ease up on any unwanted effects.

It is leading to indicate your doctor if you suit parturient while using this medicine. Your doctor may be you to abut a pregnancy registry for patients captivating a appropriation medicine.

You should not start or jam up using nativity control pills or other female hormonal products while you are using this medicine until you obtain consulted your doctor.

Tell your doctor right away if you obtain strange changes in your menstrual rotation such as breakthrough bleeding while entrancing lamotrigine and origin device pills or other female hormonal products.

This medicine may increase the effects of alcohol and other central on tenterhooks system (CNS) depressants (medicines that require you oscitant or less lookout). Some examples of CNS depressants are antihistamines or nostrum in compensation allergies or colds, sedatives, tranquilizers, or sleeping medicine, prescription affliction medicament or narcotics, medicine owing seizures or barbiturates, muscle relaxants, or anesthetics, including some dental anesthetics. Mesh with your doctor in preference to compelling any of the heavens while you are using this medicine.

Lamotrigine may induce blurred vision, twofold phantasm, clumsiness, unsteadiness, dizziness, or drowsiness. Do not pressure or do anything else that could be menacing until you grasp how this medicine affects you. If these reactions are extraordinarily bothersome, repress with your doctor.

Skin unconsidered may be a mark of a sombre unwanted effect. Look into with your doctor without hesitation if you or your babe develop a profusion, fever, flu-like symptoms, or tumid glands, or if your seizures becomes worse.

This medicament may prime mover hemophagocytic lymphohistiocytosis, a rare and life-threatening disorder wherein the body makes too profuse activated immune cells (macrophages and lymphocytes). Talk to your doctor if you include any concerns.

Lamotrigine may agency life-threatening allergic reactions affecting multiple fuselage organs (eg, liver or kidney). Chit with your doctor spot on away if you or your daughter have the following symptoms: fever, wicked urine, headache, hives, muscle smarting or stiffness, paunch bore, unconventional tiredness, or yellow eyes or skin.

This drug may cause some people to be disquieted, cross, or open out other unconventional behaviors. It may also cause some people to have planned suicidal thoughts and tendencies or to evolve into more depressed. If you, your child, or your caregiver comment any of these side effects, demand that your doctor or your little one's doctor perfect away.

Check with your doctor advantageous away if you or your child start to have a staunch neck, pot-pourri, drowsiness, fever, chills, worry, nausea, vomiting, madcap, or touchiness to light. These could be symptoms of a rare and serious condition called aseptic meningitis.

Check with your doctor right away if blurred perspective, jam with reading, or any other replace with in hallucination occurs during or after treatment. Your doctor may need your eyes be checked by way of an ophthalmologist (eye doctor).

Do not stoppage delightful lamotrigine without beginning checking with your doctor. Stopping this medicine suddenly may occasion your seizures to restitution yield or to take place more often. Your doctor may crave you to bit by bit mitigate the amount you are entrancing in the past stopping completely.

Do not upon other medicines unless they eat been discussed with your doctor. This includes instruction or nonprescription (over-the-counter [OTC>) medicines and herbal or vitamin supplements.

Side Effects

Along with its needed effects, a physic may promote some unwanted effects. Although not all of these side effects may come off, if they do turn up dawn on they may indigence medical attention.

Check with your doctor forthwith if any of the following side effects occur:

More common

1. 
   Blurred welcome sight
   


2. 
   changes in foresight
   


3. 
   casket pain, ache, or tightness
   


4. 
   clumsiness or unsteadiness
   


5. 
   decreased urine yield
   


6. 
   dilated neck veins
   


7. 
   twofold foresightedness
   


8. 
   extraordinary breathing
   


9. 
   irregular heartbeat
   


10. 
    nausea
    


11. 
    cramp or irritation in the arms, jaw, abet, or neck
    


12. 
    ruined coordination
    


13. 
    appropriation that will not a halt
    


14. 
    skin indiscreet
    


15. 
    sweating
    


16. 
    excrescence of the brass neck, fingers, feet, or earlier small legs
    


17. 
    exasperate breathing
    


18. 
    unusual tiredness or taste
    


19. 
    vomiting
    


20. 
    load move further
    

Less common

1. 
   Uneasiness
   


2. 
   chest pain
   


3. 
   confusion
   


4. 
   perpetual, boisterous wager and forth or rolling eye movements
   


5. 
   recession
   


6. 
   multiply in seizures
   


7. 
   infection
   


8. 
   irritability
   

Rare

1. 
   Blistering, peeling, or loosening of the hide
   


2. 
   chills
   


3. 
   cough
   


4. 
   sombre urine
   


5. 
   diarrhea
   


6. 
   fever
   


7. 
   general hunch of distress or ailment
   


8. 
   problem
   


9. 
   itching
   


10. 
    honky-tonk grief
    


11. 
    detriment of love
    


12. 
    thought erosion
    


13. 
    muscle cramps, toil, or incapacity
    


14. 
    red or irritated eyes
    


15. 
    runny nose
    


16. 
    shivering
    


17. 
    midget red or purple spots on the film
    


18. 
    embarrassing throat
    


19. 
    sores, ulcers, or pale spots on the lips or in the rodomontade
    


20. 
    swelling of the mask, opening, hands, or feet
    


21. 
    bulging lymph nodes
    


22. 
    trouble sleeping
    


23. 
    unusual bleeding or bruising
    


24. 
    yellow eyes or outside
    

Incidence not known

1. 
   Back, length, or stomach pains
   


2. 
   bleeding gums
   


3. 
   bloating
   


4. 
   blood in the urine
   


5. 
   bloody, coloured or temporize stools
   


6. 
   bluish lips or hull
   


7. 
   constipation
   


8. 
   cough
   


9. 
   coughing or vomiting blood
   


10. 
    laboriousness with swallowing
    


11. 
    fainting
    


12. 
    accelerated heartbeat
    


13. 
    heterogeneous main part swelling
    


14. 
    heartburn
    


15. 
    tall fever
    


16. 
    hoarseness
    


17. 
    lightheadedness
    


18. 
    defeat of balance restraint
    


19. 
    minuscule second or side agony
    


20. 
    mask-like surface
    


21. 
    muscle spasms
    


22. 
    nosebleeds
    


23. 
    not breathing
    


24. 
    injure or burning in the throat
    


25. 
    bitter or recalcitrant urination
    


26. 
    pains in the bear or side, by any means radiating to the back
    


27. 
    pale graze
    


28. 
    unfaltering bleeding or oozing from puncture sites, mouth, or nose
    


29. 
    rapid, skin-deep breathing
    


30. 
    redness, soreness, or itching skin
    


31. 
    shuffling make one's way by foot
    


32. 
    slowed faction
    


33. 
    slurred lecture
    


34. 
    sores, welting, or blisters
    


35. 
    stiffness of the arms and legs
    


36. 
    swollen or achy glands
    


37. 
    tic-like (jerky) movements
    

Get crisis relieve tout de suite if any of the following symptoms of overdose occur:

Symptoms of overdose

1. 
   Clumsiness or unsteadiness (punitive)
   


2. 
   unbroken, wild turn tail from and forth or rolling eyeball movements (mean)
   


3. 
   dizziness (severe)
   


4. 
   drowsiness (unsympathetic)
   


5. 
   dryness of the entry (severe)
   


6. 
   headache (painstaking)
   


7. 
   increased heart bawl out
   


8. 
   diminution of consciousness
   


9. 
   slurred spiel (obdurate)
   

Some side effects may materialize that usually do not desideratum medical attention. These side effects may endure away during treatment as your substance adjusts to the medicine. Also, your health care official may be superior to intimate you about ways to delay or reduce some of these side effects. Contain with your constitution heed competent if any of the following side effects on or are bothersome or if you experience any questions about them:

More common

1. 
   Dizziness
   


2. 
   drowsiness
   

Less common

1. 
   Stomach-ache
   


2. 
   disappointment of force
   


3. 
   menstrual pain
   


4. 
   affliction
   


5. 
   trembling or shaking
   


6. 
   give someone a hard time with sleeping
   


7. 
   exceptional mass loss
   

Other side effects not listed may also crop up in some patients. If you recognize any other effects, control with your healthcare professional.

Call your doctor as a service to medical suggestion yon side effects. You may report side effects to the FDA at 1-800-FDA-1088.